Microwave Peptide Instrument

Microwave peptide instrument from AAPPTec, Infinity 2400™, helps chemists prepare long or difficult peptides in higher yield and better purity. The Infinity 2400™ provides capacity and flexibility unequaled by other microwave peptide instruments on the market.

Microwave Peptide Synthesis

Microwaves rapidly heat reaction mixtures through interaction of molecular dipoles with the electromagnetic field of the microwaves.  This interaction increases the molecular vibrations, which raises the temperature.  The increased molecular vibration accelerates the reaction by increasing the rate at which molecule collide with each other, thus increasing the probability of a reaction.  The increased vibration of the peptide chains also reduces the probabilility that they will adopt unfavorable coformations in which the reactive site is inaccessible. 

Microwave heating is not always beneficial.  At higher temperatures, undesired side reactions are also accelerated.  Cysteine and histidine become more susceptible to racemization during coupling at elevated temperatures, for instance.  If a reaction proceeds rapidly in high yield at room temperature, microwave heating is not likely to have a significant positive impact.  Indeed, heating may accelerate side reactions and result in a crude product with lower purity and reduced yield.  The Infinity 2000 allows chemists to utilize microwave heating only when they choose.

Infinity 2400™ Microwave Peptide Instrument Features and Capabilities

  • Microwave up to 6 reactors at the same time
  • Interchangable reactors from 5 mL up to 300 mL
  • On-demand microwave and conventional heating
  • Precise temperature control without overshoot
  • Separate preactivation vessels
  • Optional chilling of preactivated amino acid solutions
  • Optional UV monitoring of Fmoc removal
  • 24 large capacity amino acid vessels
  • Performs up to 880 couplings unattended

The Infinity 2400™ microwave peptide instrument allows chemists to use microwave heating only when coupling reactions are slow or incomplete due to aggregation and steric hindrance, thus preventing damage to the peptide from unneccessary heating.

AAPPTec provides everything for peptide synthesis: Fmoc-Amino Acids, Boc-Amino Acids, Unusual Amino Acids, Peptide Synthesis Resins, Peptide Synthesis Reagents, Peptide Synthesizers, Evaporators, HPLC Systems and HPLC Columns.  For more about AAPPTec products, comtact AAPPTec or visit the AAPPTec web site www.aapptec.com

AAPPTEc, LLC Telephone: 502-968-2223

6309 Shepherdsville Road   Fax: 502-968-3338

Louisville, Kentucky  40228   E-mail: info@aapptec.com

  • Quantities and Prices

    To obtain a quotation for custom peptide synthesis, click HERE or contact AAPPTec by e-mail at sales@aapptec.com.
  • Contact Us

    United States Contact Information

    Thank you for visiting our website and for your interest in our company! AAPPTec has a dedicated team of chemists, engineers, technical consultants, sales representatives, and customer service representatives whom are waiting to hear from you. We look forward to speaking with you and working with you on all of your peptide-related needs.

    Address: 6309 Shepherdsville Road Louisville, KY 40228-1027

    Toll-Free Telephone: (888) 692-9111

    Telephone: (502) 968-2223

    Emails: info@aapptec.com, sales@aapptec.com

    Fax: (502) 968-3338

    Business Hours: Monday-Friday, 8am-6pm EST

    AAPPTec has representative all over the world. For contact information on the representative nearest you, please go to www.aapptec.com.

  • About Us

    AAPPTec, located in Louisville, KY, USA, offers custom peptides in quantities from mg to kg, in purities from crude to 98%, all at an affordable price. In addition to standard peptides, we also provide custom peptides with modifications such as cyclization, phosphorylation, acetylation, fluorescent labels, etc.

    Our Production Team has decades of experience in preparing high quality peptides, including long peptides, difficult peptides and peptides with special modifications.

    Our Customer Support Team has many years of experience in the peptide business and they are ready to help you with questions, orders, etc.

    AAPPTec continually strives to provide the latest technology, the most competitive prices and the highest standard of customer support to peptide chemists worldwide.

    We welcome your suggestions regarding our products and customer support. Please tell us how we can better serve you.

    Please send your suggestions to info@aapptec.com

  • What's News

    For upcoming shows, click HERE For the AAPPTec newletter Peptide News, click HERE For recent publications about peptides and proteins, click HERE.
  • FAQ

    1. How do I request a quote for my peptide?

    To request an instant quote, please sign up a free account with us and proceed to the peptide order page. If you do not have an account with us yet and would like to receive a quote for your peptide(s), please email us: www.aapptec.com or call us at 1-888-692-9111 and ask for a peptide service representative.

    2. What type of chemistry do you use?

    AAPPTec generally utilizes Fmoc chemistry for most peptide production.

    3. How do you generally purify your peptides?

    Our peptides are generally purified by preparative reversed phase HPLC, using trifluoroacetic acid (TFA) modified buffers at pH 2. Buffer A is 0.1 % TFA deionized water and buffer B is 0.1 % TFA in acetonitrile (ACN) at pH 2. Peptides are dissolved in either straight buffer A, or some amount of buffer B then diluted with buffer A.

    Sometimes it is necessary to use an organic polar solvent like (formic acid or acetic acid) in DMSO or DMF to aid in the dissolving of hydrophobic peptides but this is done on a case-by-case basis depending on the sequence analysis. The separation is monitored by UV at 214 nm and fractions are collected and analyzed by mass spectrometry for product identity and by reversed phase analytical HPLC for purity.

    The fractions are then lyophilized to remove the solvents. The fractions that meet the specifications of the order are then combined into one vial. Next, we run a final mass spectrum and analytical HPLC on the combined material.

AAPPTec offers Custom Peptides Catalog Peptides Immunology Polyclonal Antibodies Monoclonal Antibodies Amino Acids Synthesis Resins Coupling Reagents Bulk Amino Acids Bulk Synthesiz resins Bulk Coupling Reagents Peptide Synthesizers Freeze Dryers HPLC Systems HPLC Columns AAPPTec is your one source for peptides and peptide synthesis.